Watch CYT-6091 in Action

We injected CYT-6091, CytImmune’s 1st generation nanomedicine, into a mouse with a tumor. We also injected a protein called albumin, to which a florescent dye was attached. This allowed us to track the albumin as it moved through blood vessels of the mouse.

The albumin remains inside healthy tissue blood vessels, but easily passes through tumor blood vessels because CYT-6091 has destroyed the epithelial cells that make up the blood vessel walls.

 

3 Comments Add yours

  1. marcusfoxx says:

    What happens with just albumin through tumour cells?

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  2. cytimmune says:

    Great question. First, to be clear, we’re talking about albumin moving through the tumor blood vessels and into the space between the tumor cells. Prior to the addition of CYT-6091, the tumor blood vessels are a little bit leaky. This is because the cells making up those blood vessels are not as tightly connected as they are in a blood vessel passing through normal, healthy tissue. Because of this leakiness, large molecules can diffuse out of the blood vessels, but they don’t get very far and tend to get trapped at the edge of the blood vessel or pushed back into the blood vessel by the high pressure inside the tumor.

    Sorry for the preamble, but it’s important to answering your question:

    Albumin alone in the tumor blood vessels looks a lot like the healthy tissue vessels, except the picture is a bit cloudy because a small amount of albumin is leaking out. If you stop the video at 10 seconds, you can see this effect. However, once the Vascular Disruption agent (CYT-6091 ) goes to work, the albumin floods the tumor bed because the blood vessel are broken into non-contiguous pieces. It’s a bit like a garden hose with a pin-hole leak vs a garden hose with end cut off.

    When we do this with a real chemotherapy, we find that about 600% more chemo ends up in the tumor after we administer CYT-6091.

    Hope that helps.

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  3. marcusfoxx says:

    It does, thank you. I worked with gold nanoparticles for my Ph.D. and was reading a lot on vascular disruption and have been following your work closely. All the best.

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